AlphaFold 3 predicts complex immune interactions using protein sequences alone

Researchers at the Translational Genomics Research Institute (TGen), part of City of Hope, have developed a new approach using the artificial intelligence platform AlphaFold 3 to predict whether a T cell receptor will recognize a specific antigen based solely on its genetic sequence. The advancement could help scientists more rapidly decode immune responses to infectious diseases, tumors and other health threats.