One gene, two paths: Opposite synaptic defects linked to same intellectual disability

A research team led by Dr. Sheng Nengyin of the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences has reframed ZC4H2-associated rare disorder (ZARD)—a disorder marked by intellectual disability, developmental delays, muscle weakness and other neurological or physical abnormalities—as a "disease spectrum" rather than a condition driven by a single mechanism.