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Childhood cancers may spread by 'shape-shifting' rather than mutating

Researchers at the University of East Anglia (UK) have proposed an explanation for why some childhood tumors spread aggressively around the body despite having relatively few genetic faults. For years, experts believed cancers become more dangerous by accumulating genetic mutations that allow them to invade new tissues and evade treatment. But a new paper shows how childhood cancers may not always need extra mutations to spread.

Medical Xpress · Nov 9
Newly discovered pathway fuels production of cancer-driving proteins

A previously unknown mechanism helps cancer cells selectively produce proteins that drive tumor growth—such as KRAS—in common cancers, according to new research from The University of Texas MD Anderson Cancer Center. The findings reveal that targeting a specific enzyme may improve responses to targeted therapies and help overcome treatment resistance.

Medical Xpress · Nov 1
Malpractice Killed Mom; Opioid Giant Avoided Payout; Landmark Trial Questioned

This is a MedPage Today story. Welcome to the latest edition of Investigative Roundup, highlighting some of the best investigative reporting on healthcare each week. Malpractice Killed Mom What was supposed to be a routine procedure for a Texas mom instead became a tragic example of medical malpractice, according to reporting in Texas Monthly. Kimberly Ray had been getting injections in the lower lumbar region for pain from an old injury. But the injections stopped working, so her provider recommended getting a rhizotomy. Ray never woke up from the procedure. Her family ordered an autopsy, which found she "died as a result of complications following an injection procedure for pain." The family then hired a lawyer whose investigation found red flag after red flag associated with Integrity Wellness, the clinic where Ray sought treatment, and the medical staff associated with it. For one, the CRNA who administered anesthesia and performed the procedure wore a white coat and scrubs...

ABC News · Jan 1