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Single dose of healthy liver vesicles may protect against alcohol damage

Alcohol-related liver disease (ALD) is characterized by hepatocellular injury, oxidative stress, inflammation and extracellular matrix remodeling, yet effective therapies remain limited. New research in The American Journal of Pathology, found that a single dose of liver matrix-bound nanovesicles (MBVs) derived from healthy porcine tissue reduced liver injury, fat accumulation and oxidative stress in alcohol-fed mice, pointing to a possible new therapeutic strategy for ALD.

Medical Xpress · 9h ago
Neutrophil RAGE drives early cerebrovascular injury after subarachnoid hemorrhage

An international research team from Japan and the United States, led by Assistant Professor Hiroshi Ishii and Professor Osamu Hori, together with Professors Yasuhiko Yamamoto and Mitsutoshi Nakada of Kanazawa University, has identified neutrophil RAGE (receptor for advanced glycation end products) as a key driver of early cerebrovascular injury after subarachnoid hemorrhage (SAH).

Medical Xpress · Oct 31
Acute kidney injury up for older patients, men with OD-involved hospitalization

Acute kidney injury (AKI) occurs more often among older patients and men with drug overdose–involved hospitalizations, while severe inpatient courses disproportionately affect younger patients, according to research published in the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Medical Xpress · Oct 30