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Checkpoint immunotherapy reshapes immune environment in lymph nodes after melanoma reaches them

A new study from Mayo Clinic suggests checkpoint immunotherapy may reshape the immune environment within lymph nodes after melanoma has spread to them. Researchers found that treatment reorganized several types of immune cells and changed the behavior of certain cells, called macrophages, that can either support or suppress an immune response depending on their environment.

Medical Xpress · 17h ago
A rare case of Parkinson's disease reveals molecular changes in platelets during disease progression

A team from the Genomics and Transcriptomics of Synucleinopathies (GTS) research group at the Germans Trias i Pujol Research Institute (IGTP) has identified molecular changes in platelets associated with the progression of a rare case of early-onset Parkinson's disease. The study, published in Movement Disorders, highlights the value of these blood components as an accessible source for investigating potential biomarkers of disease progression.

Medical Xpress · 17h ago
How mental health and cancer survivorship intersect

A Stanford Medicine study identified an often-overlooked period of vulnerability for cancer survivors: Mental health disorders identified two to five years after a cancer diagnosis were associated with a 119% higher rate of death from cancer compared with patients without documented mental disorders during the same period.

Medical Xpress · 18h ago
New treatment reduces heart scarring and abnormal heart rhythms, offering a possibility for future therapies

In a study led by Baylor College of Medicine and the University of Oxford, researchers found that blocking a specific molecular interaction reduced atrial fibrosis in mouse models and cells from human patients with atrial fibrillation (AF), reduced fibrotic responses in human cells, and in the mouse models reversed established atrial fibrosis and reduced abnormal heart rhythms.

Medical Xpress · 18h ago
Why some patients quit a newer insomnia medication

Researchers from Rutgers and other universities analyzed hundreds of online reviews on lemborexant—and learned that about 1 in 4 of the reviewers stopped or planned to stop taking the prescription medication used to treat insomnia.

Medical Xpress · 18h ago
Platelets may play an unexpected role in glioblastoma progression

New Cleveland Clinic research published in Cancer Cell shows that people with glioblastoma have more active platelets, which are cells involved in blood clotting. Platelets also communicate with other cells and can influence immune activity. The overactive platelets in people with glioblastoma slow the activity of cancer-fighting T cells, which can contribute to tumor growth and cancer progression.

Medical Xpress · 18h ago
Beyond treating symptoms: Life stories support mental health recovery

UT research shows how personal life stories can support treatment and personal recovery. Who are you, what has shaped you, and how do you see your future? For people with personality disorders, these questions can play an important role in their recovery. Ph.D. research by clinical psychologist and psychotherapist Silvia Pol shows that paying attention to personal life stories can help guide treatment decisions and support personal recovery.

Medical Xpress · 19h ago
Safer solutions: The urgent connection between smoking and HIV

People with HIV now lose more years of life to smoking than to HIV itself. About 1.2 million Americans are living with HIV, and while smoking among U.S. adults has fallen below 10% for the first time, people with HIV still smoke at up to four times that rate. Although many people with HIV want to quit smoking, their quit rates are much lower compared to the general population.

Medical Xpress · 19h ago
Hospitalized medical patients may fare better when treated by female physicians, study finds

Patients cared for by female physicians in the hospital were less likely to die or be readmitted than those treated by male physicians, according to a new ICES study led by a University of Toronto researcher. This suggests that care by female physicians may be associated with better short- and long-term outcomes among patients hospitalized with common medical diagnoses.

Medical Xpress · 20h ago
One in four Americans have exaggerated or made up symptoms to try to get antibiotics

More than a quarter of Americans have exaggerated or made up symptoms to try to get antibiotics from their doctor, either for themselves or for their children, a new study has found. The survey of nearly 1,000 people nationwide uncovered common motivations for misrepresenting symptoms, including feeling very sick or needing to return to work or school.

Medical Xpress · 20h ago