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AlphaFold 3 predicts complex immune interactions using protein sequences alone

Researchers at the Translational Genomics Research Institute (TGen), part of City of Hope, have developed a new approach using the artificial intelligence platform AlphaFold 3 to predict whether a T cell receptor will recognize a specific antigen based solely on its genetic sequence. The advancement could help scientists more rapidly decode immune responses to infectious diseases, tumors and other health threats.

Phys.org · Nov 4
Beyond visitor numbers: Understanding overtourism risk in suburban Tokyo

Overtourism has become a growing concern in popular tourist destinations, where large numbers of visitors can put pressure on local communities and attractions. However, not all destinations face the same challenges. While busy city centers may struggle to manage crowds, less-visited suburban areas often face the opposite problem: attracting enough visitors. As tourism develops in these areas, an important question arises: Could places that currently receive relatively few visitors face new pressures as tourism grows?

Phys.org · Nov 2
Tributes paid to ‘inspiring’ University of Cambridge scientist who died in Spanish train crash

Dr Marta Shahbazi was travelling to a conference to receive an award for scientific excellence in developmental biology An “inspiring” University of Cambridge scientist died in the Spanish train collision on Wednesday which killed at least 69 people. Dr Marta Shahbazi , an affiliate associate professor at the Cambridge Stem Cell Institute and a group leader at the city’s Medical Research Council Laboratory of Molecular Biology (LMB), was travelling on one of the trains involved in the crash near Urda in Toledo province. Continue reading...

The Guardian · Nov 1
How rising seas transformed dry land into Venice lagoon

Scientists uncover ancient hills and swamps that disappeared as sea levels rose across northern Adriatic Venice is famed for being a floating city, but research shows the land it sits on once lay many miles inland. Dramatic changes in sea level over 10,000 years have reshaped the northern Adriatic coastline, with much of the land that our ancestors roamed now lying beneath the waves. Samuele Ongaro, at the University of Southampton, and colleagues combined seismic data with sedimentary cores from the coastal basins of northern Italy, Slovenia and northern Croatia to model changes in sea level across the region and reconstruct past landscapes over the past 10,000 years. Continue reading...

The Guardian · Oct 28